{"id":7660,"date":"2015-04-09T10:23:03","date_gmt":"2015-04-09T03:23:03","guid":{"rendered":"http:\/\/www.ggb.vn\/?page_id=7660"},"modified":"2017-08-30T09:21:45","modified_gmt":"2017-08-30T02:21:45","slug":"te-bao-goc-tu-mo-mo","status":"publish","type":"page","link":"http:\/\/www.ggb.vn\/?page_id=7660","title":{"rendered":"T\u1ebf b\u00e0o g\u1ed1c t\u1eeb m\u00f4 m\u1ee1"},"content":{"rendered":"<div class=\"vc_row wpb_row vc_row-fluid\"  >\n\t<div class=\"vc_col-sm-12 wpb_column vc_column_container \">\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<div class=\"wpb_revslider_element wpb_content_element\">\n<div id=\"rev_slider_10_1_wrapper\" class=\"rev_slider_wrapper fullwidthbanner-container\" style=\"margin:0px auto;background-color:#E9E9E9;padding:0px;margin-top:0px;margin-bottom:0px;max-height:350px;\">\n<!-- START REVOLUTION SLIDER 4.6.3 fullwidth mode -->\n\t<div id=\"rev_slider_10_1\" class=\"rev_slider fullwidthabanner\" style=\"display:none;max-height:350px;height:350px;\">\n<ul>\t<!-- SLIDE  -->\n\t<li data-transition=\"random\" data-slotamount=\"7\" data-masterspeed=\"300\"  data-saveperformance=\"off\" >\n\t\t<!-- MAIN IMAGE -->\n\t\t<img decoding=\"async\" src=\"http:\/\/www.ggb.vn\/wp-content\/uploads\/shutterstock_116712640.jpg\"  alt=\"shutterstock_116712640\"  data-bgposition=\"center top\" data-bgfit=\"cover\" data-bgrepeat=\"no-repeat\">\n\t\t<!-- LAYERS -->\n\n\t\t<!-- LAYER NR. 1 -->\n\t\t<div class=\"tp-caption medium_bg_red tp-fade tp-resizeme\" \n\t\t\t data-x=\"58\" \n\t\t\t data-y=\"214\"  \n\t\t\tdata-speed=\"300\" \n\t\t\tdata-start=\"500\" \n\t\t\tdata-easing=\"Power3.easeInOut\" \n\t\t\tdata-splitin=\"none\" \n\t\t\tdata-splitout=\"none\" \n\t\t\tdata-elementdelay=\"0.1\" \n\t\t\tdata-endelementdelay=\"0.1\" \n\t\t\t data-endspeed=\"300\" \n\n\t\t\tstyle=\"z-index: 5; max-width: auto; max-height: auto; white-space: nowrap;\">C\u00f4ng ngh\u1ec7 t\u1ebf b\u00e0o g\u1ed1c \n\t\t<\/div>\n\t<\/li>\n\t<!-- SLIDE  -->\n\t<li data-transition=\"random\" data-slotamount=\"7\" data-masterspeed=\"300\"  data-saveperformance=\"off\" >\n\t\t<!-- MAIN IMAGE -->\n\t\t<img decoding=\"async\" src=\"http:\/\/www.ggb.vn\/wp-content\/uploads\/bigstockphoto_Mature_Couple_In_A_Playful_Moo_51068373.jpg\"  alt=\"bigstockphoto_Mature_Couple_In_A_Playful_Moo_51068373\"  data-bgposition=\"center top\" data-kenburns=\"on\" data-duration=\"9000\" data-ease=\"Linear.easeNone\" data-bgfit=\"100\" data-bgfitend=\"100\" data-bgpositionend=\"center bottom\">\n\t\t<!-- LAYERS -->\n\n\t\t<!-- LAYER NR. 1 -->\n\t\t<div class=\"tp-caption largepinkbg tp-fade tp-resizeme\" \n\t\t\t data-x=\"318\" \n\t\t\t data-y=\"169\"  \n\t\t\tdata-speed=\"300\" \n\t\t\tdata-start=\"500\" \n\t\t\tdata-easing=\"Power3.easeInOut\" \n\t\t\tdata-splitin=\"none\" \n\t\t\tdata-splitout=\"none\" \n\t\t\tdata-elementdelay=\"0.1\" \n\t\t\tdata-endelementdelay=\"0.1\" \n\t\t\t data-endspeed=\"300\" \n\n\t\t\tstyle=\"z-index: 5; max-width: auto; max-height: auto; white-space: nowrap;\">Ch\u1ed1ng l\u00e3o h\u00f3a v\u00e0 c\u1ea3i thi\u1ec7n m\u1ed9t nh\u00f3m c\u00e1c b\u1ec7nh tho\u00e1i h\u00f3a. \n\t\t<\/div>\n\t<\/li>\n\t<!-- SLIDE  -->\n\t<li data-transition=\"random\" data-slotamount=\"7\" data-masterspeed=\"300\"  data-saveperformance=\"off\" >\n\t\t<!-- MAIN IMAGE -->\n\t\t<img decoding=\"async\" src=\"http:\/\/www.ggb.vn\/wp-content\/uploads\/9efa7cc64709ddf1f2684ff73879d330.jpg\"  alt=\"9efa7cc64709ddf1f2684ff73879d330\"  data-bgposition=\"center top\" data-kenburns=\"on\" data-duration=\"9000\" data-ease=\"Linear.easeNone\" data-bgfit=\"100\" data-bgfitend=\"100\" data-bgpositionend=\"center bottom\">\n\t\t<!-- LAYERS -->\n\t<\/li>\n\t<!-- SLIDE  -->\n\t<li data-transition=\"random\" data-slotamount=\"7\" data-masterspeed=\"300\"  data-saveperformance=\"off\" >\n\t\t<!-- MAIN IMAGE -->\n\t\t<img decoding=\"async\" src=\"http:\/\/www.ggb.vn\/wp-content\/uploads\/635693250846928291-1420881856_Tiger.jpg\"  alt=\"635693250846928291-1420881856_Tiger\"  data-bgposition=\"center top\" data-kenburns=\"on\" data-duration=\"9000\" data-ease=\"Linear.easeNone\" data-bgfit=\"100\" data-bgfitend=\"100\" data-bgpositionend=\"center bottom\">\n\t\t<!-- LAYERS -->\n\n\t\t<!-- LAYER NR. 1 -->\n\t\t<div class=\"tp-caption medium_text tp-fade tp-resizeme\" \n\t\t\t data-x=\"8\" \n\t\t\t data-y=\"265\"  \n\t\t\tdata-speed=\"300\" \n\t\t\tdata-start=\"500\" \n\t\t\tdata-easing=\"Power3.easeInOut\" \n\t\t\tdata-splitin=\"none\" \n\t\t\tdata-splitout=\"none\" \n\t\t\tdata-elementdelay=\"0.1\" \n\t\t\tdata-endelementdelay=\"0.1\" \n\t\t\t data-endspeed=\"300\" \n\n\t\t\tstyle=\"z-index: 5; max-width: auto; max-height: auto; white-space: nowrap;\">C\u00e1c v\u1eadn \u0111\u1ed9ng vi\u00ean s\u1eed d\u1ee5ng c\u00f4ng ngh\u1ec7 PRP ADISTEM \n\t\t<\/div>\n\t<\/li>\n<\/ul>\n<div class=\"tp-bannertimer\"><\/div>\t<\/div>\n\t\t\t\n\n\t\t\t<style scoped>.tp-caption.medium_text,.medium_text{position:absolute;color:#fff;text-shadow:0px 2px 5px rgba(0,0,0,0.5);font-weight:700;font-size:20px;line-height:20px;font-family:Arial;margin:0px;border-width:0px;border-style:none;white-space:nowrap}.tp-caption.largepinkbg,.largepinkbg{font-size:23px;line-height:31px;font-weight:300;font-family:\"Open Sans\";color:rgb(255,255,255);text-decoration:none;padding:0px 20px;text-shadow:none;background-color:rgb(219,67,96);border-width:0px;border-color:rgb(255,255,255);border-style:none}.tp-caption.medium_bg_red,.medium_bg_red{font-size:20px;line-height:20px;font-weight:800;font-family:\"Open Sans\";color:rgb(255,255,255);text-decoration:none;background-color:rgb(227,58,12);padding:10px;border-width:0px;border-color:rgb(255,214,88);border-style:none}<\/style>\n\n\t\t\t<script type=\"text\/javascript\">\n\n\t\t\t\t\/******************************************\n\t\t\t\t\t-\tPREPARE PLACEHOLDER FOR SLIDER\t-\n\t\t\t\t******************************************\/\n\t\t\t\t\n\n\t\t\t\tvar setREVStartSize = function() {\n\t\t\t\t\tvar\ttpopt = new Object();\n\t\t\t\t\t\ttpopt.startwidth = 960;\n\t\t\t\t\t\ttpopt.startheight = 350;\n\t\t\t\t\t\ttpopt.container = jQuery('#rev_slider_10_1');\n\t\t\t\t\t\ttpopt.fullScreen = \"off\";\n\t\t\t\t\t\ttpopt.forceFullWidth=\"off\";\n\n\t\t\t\t\ttpopt.container.closest(\".rev_slider_wrapper\").css({height:tpopt.container.height()});tpopt.width=parseInt(tpopt.container.width(),0);tpopt.height=parseInt(tpopt.container.height(),0);tpopt.bw=tpopt.width\/tpopt.startwidth;tpopt.bh=tpopt.height\/tpopt.startheight;if(tpopt.bh>tpopt.bw)tpopt.bh=tpopt.bw;if(tpopt.bh<tpopt.bw)tpopt.bw=tpopt.bh;if(tpopt.bw<tpopt.bh)tpopt.bh=tpopt.bw;if(tpopt.bh>1){tpopt.bw=1;tpopt.bh=1}if(tpopt.bw>1){tpopt.bw=1;tpopt.bh=1}tpopt.height=Math.round(tpopt.startheight*(tpopt.width\/tpopt.startwidth));if(tpopt.height>tpopt.startheight&&tpopt.autoHeight!=\"on\")tpopt.height=tpopt.startheight;if(tpopt.fullScreen==\"on\"){tpopt.height=tpopt.bw*tpopt.startheight;var cow=tpopt.container.parent().width();var coh=jQuery(window).height();if(tpopt.fullScreenOffsetContainer!=undefined){try{var offcontainers=tpopt.fullScreenOffsetContainer.split(\",\");jQuery.each(offcontainers,function(e,t){coh=coh-jQuery(t).outerHeight(true);if(coh<tpopt.minFullScreenHeight)coh=tpopt.minFullScreenHeight})}catch(e){}}tpopt.container.parent().height(coh);tpopt.container.height(coh);tpopt.container.closest(\".rev_slider_wrapper\").height(coh);tpopt.container.closest(\".forcefullwidth_wrapper_tp_banner\").find(\".tp-fullwidth-forcer\").height(coh);tpopt.container.css({height:\"100%\"});tpopt.height=coh;}else{tpopt.container.height(tpopt.height);tpopt.container.closest(\".rev_slider_wrapper\").height(tpopt.height);tpopt.container.closest(\".forcefullwidth_wrapper_tp_banner\").find(\".tp-fullwidth-forcer\").height(tpopt.height);}\n\t\t\t\t};\n\n\t\t\t\t\/* CALL PLACEHOLDER *\/\n\t\t\t\tsetREVStartSize();\n\n\n\t\t\t\tvar tpj=jQuery;\n\t\t\t\ttpj.noConflict();\n\t\t\t\tvar revapi10;\n\n\t\t\t\ttpj(document).ready(function() {\n\n\t\t\t\tif(tpj('#rev_slider_10_1').revolution == undefined){\n\t\t\t\t\trevslider_showDoubleJqueryError('#rev_slider_10_1');\n\t\t\t\t}else{\n\t\t\t\t   revapi10 = tpj('#rev_slider_10_1').show().revolution(\n\t\t\t\t\t{\t\n\t\t\t\t\t\t\t\t\t\t\t\tdottedOverlay:\"none\",\n\t\t\t\t\t\tdelay:9000,\n\t\t\t\t\t\tstartwidth:960,\n\t\t\t\t\t\tstartheight:350,\n\t\t\t\t\t\thideThumbs:200,\n\n\t\t\t\t\t\tthumbWidth:100,\n\t\t\t\t\t\tthumbHeight:50,\n\t\t\t\t\t\tthumbAmount:4,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\tsimplifyAll:\"off\",\n\n\t\t\t\t\t\tnavigationType:\"bullet\",\n\t\t\t\t\t\tnavigationArrows:\"solo\",\n\t\t\t\t\t\tnavigationStyle:\"round\",\n\n\t\t\t\t\t\ttouchenabled:\"on\",\n\t\t\t\t\t\tonHoverStop:\"on\",\n\t\t\t\t\t\tnextSlideOnWindowFocus:\"off\",\n\n\t\t\t\t\t\tswipe_threshold: 75,\n\t\t\t\t\t\tswipe_min_touches: 1,\n\t\t\t\t\t\tdrag_block_vertical: false,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\tkeyboardNavigation:\"off\",\n\n\t\t\t\t\t\tnavigationHAlign:\"center\",\n\t\t\t\t\t\tnavigationVAlign:\"bottom\",\n\t\t\t\t\t\tnavigationHOffset:0,\n\t\t\t\t\t\tnavigationVOffset:20,\n\n\t\t\t\t\t\tsoloArrowLeftHalign:\"left\",\n\t\t\t\t\t\tsoloArrowLeftValign:\"center\",\n\t\t\t\t\t\tsoloArrowLeftHOffset:20,\n\t\t\t\t\t\tsoloArrowLeftVOffset:0,\n\n\t\t\t\t\t\tsoloArrowRightHalign:\"right\",\n\t\t\t\t\t\tsoloArrowRightValign:\"center\",\n\t\t\t\t\t\tsoloArrowRightHOffset:20,\n\t\t\t\t\t\tsoloArrowRightVOffset:0,\n\n\t\t\t\t\t\tshadow:0,\n\t\t\t\t\t\tfullWidth:\"on\",\n\t\t\t\t\t\tfullScreen:\"off\",\n\n\t\t\t\t\t\t\t\t\t\t\t\tspinner:\"spinner0\",\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\tstopLoop:\"off\",\n\t\t\t\t\t\tstopAfterLoops:-1,\n\t\t\t\t\t\tstopAtSlide:-1,\n\n\t\t\t\t\t\tshuffle:\"off\",\n\n\t\t\t\t\t\tautoHeight:\"off\",\n\t\t\t\t\t\tforceFullWidth:\"off\",\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\thideThumbsOnMobile:\"off\",\n\t\t\t\t\t\thideNavDelayOnMobile:1500,\n\t\t\t\t\t\thideBulletsOnMobile:\"off\",\n\t\t\t\t\t\thideArrowsOnMobile:\"off\",\n\t\t\t\t\t\thideThumbsUnderResolution:0,\n\n\t\t\t\t\t\t\t\t\t\t\t\thideSliderAtLimit:0,\n\t\t\t\t\t\thideCaptionAtLimit:0,\n\t\t\t\t\t\thideAllCaptionAtLilmit:0,\n\t\t\t\t\t\tstartWithSlide:0\t\t\t\t\t});\n\n\n\n\t\t\t\t\t\t\t\t\t}\n\t\t\t\t});\t\/*ready*\/\n\n\t\t\t<\/script>\n\n\n\t\t\t<\/div><!-- END REVOLUTION SLIDER --><\/div>\n\n\t\t<\/div> \n\t<\/div> \n<\/div><div class=\"opn-row-pre-element\" data-opn_enable_overlay=\"\" data-id=\"\" data-gutter=\"\"><\/div>\t<div class=\"vc_row wpb_row vc_row-fluid\"  >\n\t<div class=\"vc_col-sm-8 wpb_column vc_column_container \">\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t\n\t<div class=\"wpb_text_column wpb_content_element \">\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<h2>T\u1ed5ng quan v\u1ec1 t\u1ebf b\u00e0o g\u1ed1c<\/h2>\n<p><strong>T\u1ebf b\u00e0o G\u1ed1c l\u00e0 g\u00ec?<\/strong><\/p>\n<p>C\u00e1c t\u1ebf b\u00e0o g\u1ed1c l\u00e0 nh\u1eefng t\u1ebf b\u00e0o c\u01a1 s\u1edf \u0111\u1ec3 t\u1ea1o n\u00ean t\u1ea5t c\u1ea3 c\u00e1c c\u01a1 quan t\u1ed5 ch\u1ee9c c\u1ee7a c\u01a1 th\u1ec3. Nh\u1eefng t\u1ebf b\u00e0o n\u00e0y kh\u00f4ng ch\u1ec9 c\u00f3 kh\u1ea3 n\u0103ng l\u00e0m m\u1edbi m\u00ecnh th\u00f4ng qua qu\u00e1 tr\u00ecnh t\u1ef1 ph\u00e2n chia m\u00e0 c\u00f2n c\u00f3 kh\u1ea3 n\u0103ng bi\u1ec7t h\u00f3a th\u00e0nh nhi\u1ec1u lo\u1ea1i t\u1ebf b\u00e0o kh\u00e1c nhau. Nghi\u00ean c\u1ee9u t\u1ebf b\u00e0o g\u1ed1c \u1edf ng\u01b0\u1eddi \u0111\u01b0\u1ee3c b\u1eaft \u0111\u1ea7u t\u1eeb nh\u1eefng k\u1ebft qu\u1ea3 nghi\u00ean c\u1ee9u c\u1ee7a nh\u00e0 khoa h\u1ecdc ng\u01b0\u1eddi Canada Ernest A. McCulloch v\u00e0 James E. Till v\u00e0o nh\u1eefng n\u0103m 1960.<\/p>\n<h2><a name=\"_Toc381266968\"><\/a>1.\u00a0\u00a0\u00a0\u00a0\u00a0 <span style=\"text-decoration: underline;\">C\u00e1c lo\u1ea1i t\u1ebf b\u00e0o g\u1ed1c<\/span><\/h2>\n<p>C\u00f3 nhi\u1ec1u c\u00e1ch ph\u00e2n lo\u1ea1i t\u1ebf b\u00e0o g\u1ed1c kh\u00e1c nhau theo ngu\u1ed3n g\u1ed1c l\u00e1 ph\u00f4i (t\u1ebf b\u00e0o g\u1ed1c trung m\u00f4); theo ngu\u1ed3n g\u1ed1c khai th\u00e1c (t\u1ebf b\u00e0o g\u1ed1c ph\u00f4i, t\u1ebf b\u00e0o g\u1ed1c t\u1ee7y, t\u1ebf b\u00e0o g\u1ed1c m\u00e1u cu\u1ed1ng r\u1ed1n\u2026); theo ti\u1ec1m n\u0103ng bi\u1ec7t h\u00f3a (t\u1ebf b\u00e0o g\u1ed1c to\u00e0n n\u0103ng, \u0111a n\u0103ng)&#8230; M\u1ed9t s\u1ed1 lo\u1ea1i t\u1ebf b\u00e0o g\u1ed1c \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u v\u00e0 \u1ee9ng d\u1ee5ng nhi\u1ec1u l\u00e0:<\/p>\n<ol>\n<li>C\u00e1c t\u1ebf b\u00e0o g\u1ed1c ph\u00f4i, c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb ph\u00f4i thai<\/li>\n<li>C\u00e1c t\u1ebf b\u00e0o g\u1ed1c tr\u01b0\u1edfng th\u00e0nh \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y trong c\u00e1c m\u00f4 tr\u01b0\u1edfng thanh<\/li>\n<li>C\u00e1c t\u1ebf b\u00e0o g\u1ed1c t\u1eeb m\u00e1u cu\u1ed1ng r\u1ed1n v\u00e0 m\u00e0ng l\u00f3t d\u00e2y r\u1ed1n<\/li>\n<li>T\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 t\u1eeb t\u1ee7y x\u01b0\u01a1ng<\/li>\n<li>T\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 t\u1eeb m\u00f4 m\u1ee1<\/li>\n<\/ol>\n<h2>2.\u00a0\u00a0\u00a0\u00a0\u00a0 <span style=\"text-decoration: underline;\">Vai tr\u00f2 c\u1ee7a c\u00e1c t\u1ebf b\u00e0o g\u1ed1c<\/span><\/h2>\n<p>Trong qu\u00e1 tr\u00ecnh ph\u00e1t tri\u1ec3n c\u1ee7a ph\u00f4i thai, c\u00e1c t\u1ebf b\u00e0o g\u1ed1c ph\u00f4i bi\u1ec7t h\u00f3a th\u00e0nh c\u00e1c m\u00f4 chuy\u00ean bi\u1ec7t c\u1ee7a ph\u00f4i thai. Ng\u01b0\u1ee3c l\u1ea1i, \u1edf c\u01a1 th\u1ec3 ng\u01b0\u1eddi tr\u01b0\u1edfng th\u00e0nh, c\u00e1c t\u1ebf b\u00e0o g\u1ed1c tr\u01b0\u1edfng th\u00e0nh v\u00e0 c\u00e1c ti\u1ec1n t\u1ebf b\u00e0o \u0111\u00f3ng vai tr\u00f2 nh\u01b0 m\u1ed9t h\u1ec7 th\u1ed1ng s\u1eeda ch\u1eefa c\u1ee7a c\u01a1 th\u1ec3 th\u00f4ng qua vi\u1ec7c bi\u1ec7t h\u00f3a th\u00e0nh c\u00e1c lo\u1ea1i t\u1ebf b\u00e0o chuy\u00ean bi\u1ec7t v\u00e0 b\u1ed5 sung cho c\u00e1c m\u00f4 b\u1ecb h\u01b0 h\u1ea1i. N\u00f3i m\u1ed9t c\u00e1ch kh\u00e1c, \u1edf c\u01a1 th\u1ec3 ng\u01b0\u1eddi tr\u01b0\u1edfng th\u00e0nh, c\u00e1c t\u1ebf b\u00e0o g\u1ed1c tr\u01b0\u1edfng th\u00e0nh \u0111\u01b0\u1ee3c d\u1eef tr\u1eef \u1edf m\u1ed9t s\u1ed1 b\u1ed9 ph\u1eadn kh\u00e1c nhau nh\u1eb1m m\u1ee5c \u0111\u00edch s\u1eeda ch\u1eefa v\u00e0 thay th\u1ebf c\u00e1c m\u00f4 b\u1ec7nh hay t\u1ed5n th\u01b0\u01a1ng. Tuy nhi\u00ean c\u0169ng c\u1ea7n l\u01b0u \u00fd r\u1eb1ng ngu\u1ed3n t\u1ebf b\u00e0o g\u1ed1c d\u1ef1 tr\u1eef n\u00e0y l\u00e0 c\u00f3 gi\u1edbi h\u1ea1n v\u00e0 gi\u1ea3m d\u1ea7n theo tu\u1ed5i, h\u1ec7 qu\u1ea3 c\u1ee7a qu\u00e1 tr\u00ecnh n\u00e0y d\u1eabn t\u1edbi s\u1ef1 xu\u1ea5t hi\u1ec7n c\u1ee7a b\u1ec7nh t\u1eadt, c\u00e1c r\u1ed1i lo\u1ea1n v\u00e0 s\u1ef1 l\u00e3o h\u00f3a c\u1ee7a c\u01a1 th\u1ec3.<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<h2><a name=\"_Toc381266970\"><\/a>3.\u00a0\u00a0\u00a0\u00a0\u00a0 <span style=\"text-decoration: underline;\">T\u1ebf b\u00e0o g\u1ed1c tr\u01b0\u1edfng th\u00e0nh l\u00e0 g\u00ec?<\/span><\/h2>\n<p>C\u00e1c t\u1ebf b\u00e0o g\u1ed1c tr\u01b0\u1edfng th\u00e0nh (ASCs) l\u00e0 nh\u1eefng t\u1ebf b\u00e0o ch\u01b0a bi\u1ec7t h\u00f3a c\u00f3 kh\u1ea3 n\u0103ng ph\u00e2n chia \u0111\u1ec3 gia t\u0103ng s\u1ed1 l\u01b0\u1ee3ng \u0111\u1ed3ng th\u1eddi c\u00f2n c\u00f3 kh\u1ea3 n\u0103ng bi\u1ec7t h\u00f3a th\u00e0nh m\u1ed9t s\u1ed1 c\u00e1c t\u1ebf b\u00e0o chuy\u00ean bi\u1ec7t \u0111\u1ec3 thay th\u1ebf cho c\u00e1c m\u00f4 b\u1ecb ch\u1ebft ho\u1eb7c t\u1ed5n th\u01b0\u01a1ng. T\u1ebf b\u00e0o g\u1ed1c tr\u01b0\u1edfng th\u00e0nh \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y c\u1ea3 \u1edf tr\u1ebb em v\u00e0 ng\u01b0\u1eddi l\u1edbn v\u00e0 c\u00f2n \u0111\u01b0\u1ee3c xem nh\u01b0 c\u00e1c t\u1ebf b\u00e0o g\u1ed1c soma.<\/p>\n<h2>\u00a0<a name=\"_Toc381266971\"><\/a>4.\u00a0\u00a0\u00a0\u00a0\u00a0 <span style=\"text-decoration: underline;\">C\u00e1c ngu\u1ed3n t\u1ebf b\u00e0o g\u1ed1c tr\u01b0\u1edfng th\u00e0nh t\u1ef1 th<\/span><span style=\"text-decoration: underline;\">\u00e2<\/span><span style=\"text-decoration: underline;\">n<\/span><\/h2>\n<p>C\u00f3 3 ngu\u1ed3n t\u1ebf b\u00e0o g\u1ed1c \u0111\u01b0\u1ee3c ph\u00e2n l\u1eadp t\u1eeb c\u01a1 th\u1ec3 ng\u01b0\u1eddi bao g\u1ed3m:<\/p>\n<ol>\n<li>T\u1ee7y x\u01b0\u01a1ng<\/li>\n<li>M\u00e1u ngo\u1ea1i bi\u00ean<\/li>\n<li>M\u00f4 m\u1ee1<\/li>\n<\/ol>\n<h2>5.\u00a0\u00a0\u00a0\u00a0\u00a0 <span style=\"text-decoration: underline;\">\u0110\u00e2u l\u00e0 ngu\u1ed3n t\u1ebf b\u00e0o g\u1ed1c tr\u01b0\u1edfng th\u00e0nh phong ph\u00fa nh\u1ea5t trong c\u01a1 th\u1ec3?<\/span><\/h2>\n<p>M\u00f4 m\u1ee1 l\u00e0 n\u01a1i cung c\u1ea5p s\u1ed1 l\u01b0\u1ee3ng t\u1ebf b\u00e0o g\u1ed1c tr\u01b0\u1edfng th\u00e0nh nhi\u1ec1u nh\u1ea5t trong c\u01a1 th\u1ec3. D\u01b0\u1edbi \u0111\u00e2y l\u00e0 so s\u00e1nh v\u1ec1 s\u1ed1 l\u01b0\u1ee3ng t\u1ebf b\u00e0o g\u1ed1c thu \u0111\u01b0\u1ee3c t\u1eeb 3 ngu\u1ed3n n\u00f3i tr\u00ean (7)<\/p>\n<ul>\n<li>T\u1ee7y x\u01b0\u01a1ng: ph\u00e2n l\u1eadp \u0111\u01b0\u1ee3c 100,000 ASCs\/l\u1ea7n. Nh\u1eefng t\u1ebf b\u00e0o g\u1ed1c n\u00e0y h\u1ea7u h\u1ebft bi\u1ec7t h\u00f3a th\u00e0nh c\u00e1c t\u1ebf b\u00e0o m\u00e1u.<\/li>\n<li>M\u00e1u ngo\u1ea1i bi\u00ean: ph\u00e2n l\u1eadp \u0111\u01b0\u1ee3c 10,000 ASCs\/l\u1ea7n. 50% trong s\u1ed1 n\u00e0y bi\u1ec7t h\u00f3a th\u00e0nh c\u00e1c t\u1ebf b\u00e0o m\u00e1u v\u00e0 50% c\u00f2n l\u1ea1i bi\u1ec7t h\u00f3a th\u00e0nh c\u00e1c t\u1ebf b\u00e0o \u1edf c\u00e1c m\u00f4.<\/li>\n<li>M\u00f4 m\u1ee1: ph\u00e2n l\u1eadp \u0111\u01b0\u1ee3c t\u1eeb 10,000,000 \u2013 50,000,000 ASCs\/l\u1ea7n. Ch\u1ec9 c\u00f3 5% trong s\u1ed1 n\u00e0y bi\u1ec7t h\u00f3a th\u00e0nh t\u1ebf b\u00e0o m\u00e1u v\u00e0 95% bi\u1ec7t h\u00f3a th\u00e0nh c\u00e1c t\u1ebf b\u00e0o \u1edf c\u00e1c m\u00f4.<\/li>\n<\/ul>\n<h2>6.\u00a0\u00a0\u00a0\u00a0\u00a0 <span style=\"text-decoration: underline;\">T\u1ea1i sao m\u00f4 m\u1ee1 l\u00e0 ngu\u1ed3n cung c\u1ea5p ASCs t\u1ed1t h\u01a1n trong s\u1ed1 c\u00e1c ngu\u1ed3n cung c\u1ea5p ASCs<\/span><\/h2>\n<p>S\u1ed1 l\u01b0\u1ee3ng r\u1ea5t l\u1edbn c\u00e1c ASCs ph\u00e2n l\u1eadp \u0111\u01b0\u1ee3c t\u1eeb m\u00f4 m\u1ee1 v\u00e0o b\u1ea5t c\u1ee9 th\u1eddi \u0111i\u1ec3m n\u00e0o cho th\u1ea5y \u0111\u00e2y l\u00e0 ngu\u1ed3n cung c\u1ea5p ASCs t\u1ed1t nh\u1ea5t c\u1ee7a c\u01a1 th\u1ec3. S\u1ed1 l\u01b0\u1ee3ng l\u1edbn ASCs thu \u0111\u01b0\u1ee3c t\u1eeb m\u00f4 m\u1ee1 n\u00e0y c\u00f3n c\u00f3 l\u1ee3i th\u1ebf l\u00e0 kh\u00f4ng c\u1ea7n nu\u00f4i c\u1ea5y \u0111\u1ec3 gia t\u0103ng s\u1ed1 l\u01b0\u1ee3ng nh\u1eb1m \u0111\u00e1p \u1ee9ng nhu c\u1ea7u v\u1ec1 m\u1eb7t s\u1ed1 l\u01b0\u1ee3ng trong \u0111i\u1ec1u tr\u1ecb &#8211; l\u1ee3i \u00edch tr\u1ecb li\u1ec7u. Th\u00eam v\u00e0o \u0111\u00f3, vi\u1ec7c thu ho\u1ea1ch ASCs t\u1eeb m\u00f4 m\u1ee1 d\u1ec5 d\u00e0ng h\u01a1n, kh\u00f4ng g\u00e2y \u0111au \u0111\u1edbn v\u00e0 \u00edt nguy c\u01a1 \u0111\u1ed1i v\u1edbi b\u1ec7nh nh\u00e2n. Ta c\u00f3 th\u1ec3 t\u00f3m t\u1eaft 3 \u01b0u \u0111i\u1ec3m ch\u00ednh nh\u01b0 sau:<\/p>\n<ol>\n<li>M\u00f4 m\u1ee1 l\u00e0 m\u00f4 ph\u1ed5 bi\u1ebfn, c\u00f3 nhi\u1ec1u trong c\u01a1 th\u1ec3 ng\u01b0\u1eddi, d\u1ec5 d\u00e0ng khai th\u00e1c, t\u00e1i t\u1ea1o \u0111\u01b0\u1ee3c<strong>. <\/strong>Th\u1ee7 thu\u1eadt ch\u1ec9 c\u1ea7n g\u00e2y t\u00ea t\u1ea1i ch\u1ed7.<\/li>\n<li>M\u00f4 m\u1ee1 l\u00e0 ngu\u1ed3n t\u1ebf b\u00e0o c\u00f3 th\u1ec3 t\u1ef1 b\u00f9 \u0111\u1eafp, s\u1ed1 l\u01b0\u1ee3ng t\u1ebf b\u00e0o thu \u0111\u01b0\u1ee3c l\u1edbn, kh\u00f4ng c\u1ea7n nu\u00f4i c\u1ea5y.<\/li>\n<li>S\u1eed d\u1ee5ng t\u1ebf b\u00e0o g\u1ed1c m\u00f4 m\u1ee1 t\u1ef1 th\u00e2n th\u00ec l\u00e0 ngu\u1ed3n t\u1ef1 gh\u00e9p, tr\u00e1nh \u0111\u01b0\u1ee3c c\u00e1c ph\u1ea3n \u1ee9ng th\u1ea3i gh\u00e9p.<\/li>\n<\/ol>\n<p>V\u1edbi c\u00e1c qu\u1ea7n th\u1ec3 phong ph\u00fa CD90<sup>(+)<\/sup> CD 105<sup>(+)<\/sup> CD 34<sup>(+)<\/sup>&#8230;c\u00f3 th\u1ec3 d\u1ef1 \u0111o\u00e1n kh\u1ea3 n\u0103ng t\u1ed1t v\u1ec1 c\u1ea3 hai h\u01b0\u1edbng bi\u1ec7t h\u00f3a th\u00e0nh c\u00e1c t\u1ebf b\u00e0o m\u00f4 s\u1edf t\u1ea1i v\u00e0 t\u0103ng sinh t\u00e2n m\u1ea1ch.<\/p>\n<p>T\u1ebf b\u00e0o g\u1ed1c m\u00f4 m\u1ee1 t\u1ef1 th\u00e2n v\u00e0 t\u1ebf b\u00e0o g\u1ed1c t\u1ee7y x\u01b0\u01a1ng \u0111\u1ec1u l\u00e0 ngu\u1ed3n t\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 (Mesenchymal Stem Cells \u2013 MSCs) c\u00f3 c\u00e1c \u0111\u1eb7c t\u00ednh v\u00e0 kh\u1ea3 n\u0103ng \u1ee9ng d\u1ee5ng kh\u00e1 t\u01b0\u01a1ng \u0111\u1ed3ng. Kh\u1ed1i t\u1ebf b\u00e0o g\u1ed1c thu \u0111\u01b0\u1ee3c t\u1eeb m\u00f4 m\u1ee1 mang c\u00e1c qu\u1ea7n th\u1ec3 CD45<sup>&#8211;<\/sup> CD34<sup>+<\/sup>, CD105<sup>+<\/sup><sup> 7<\/sup> v\u00e0 CD90<sup>+<\/sup> v\u1edbi t\u1ef7 l\u1ec7 kho\u1ea3ng 29.2% <sup>6<\/sup> c\u00f3 kh\u1ea3 n\u0103ng bi\u1ec7t h\u00f3a th\u00e0nh c\u00e1c d\u00f2ng t\u1ebf b\u00e0o s\u1ee5n, c\u01a1, m\u1ea1ch m\u00e1u&#8230;.T\u1ebf b\u00e0o g\u1ed1c CD34<sup>+<\/sup> chi\u1ebfm t\u1ef7 l\u1ec7 kho\u1ea3ng 6.8% c\u1ee7a kh\u1ed1i t\u1ebf b\u00e0o n\u1ec1n (stromal cell) ph\u00e2n l\u1eadp \u0111\u01b0\u1ee3c t\u1eeb m\u00f4 m\u1ee1.<\/p>\n<h2>7.\u00a0\u00a0\u00a0\u00a0\u00a0 <span style=\"text-decoration: underline;\">Qu\u00e1 tr\u00ecnh c\u1ea5y gh\u00e9p t\u1ebf b\u00e0o g\u1ed1c m\u00f4 m\u1ee1 t\u1ef1 th\u00e2n ti\u1ebfn h\u00e0nh nh\u01b0 th\u1ebf n\u00e0o?<\/span><\/h2>\n<p>Trong qu\u00e1 tr\u00ecnh n\u00e0y, b\u1ec7nh nh\u00e2n s\u1ebd \u0111\u01b0\u1ee3c l\u1ea5y 100 \u2013 150 ml m\u1ee1 th\u00f4ng qua th\u1ee7 thu\u1eadt h\u00fat m\u1ee1 mang t\u00ednh x\u00e2m l\u1ea5n t\u1ed1i thi\u1ec3u (k\u1ef9 thu\u1eadt l\u1ea5y m\u1ee1 b\u1ea3o t\u1ed3n t\u1ebf b\u00e0o). C\u00e1c t\u1ebf b\u00e0o g\u1ed1c \u0111ang t\u1ed3n t\u1ea1i d\u01b0\u1edbi d\u1ea1ng ch\u01b0a ho\u1ea1t \u0111\u1ed9ng thu \u0111\u01b0\u1ee3c sau qu\u00e1 tr\u00ecnh ph\u00e2n l\u1eadp t\u1eeb\u00a0 m\u1ee1 s\u1ebd \u0111\u01b0\u1ee3c k\u00edch ho\u1ea1t b\u1eb1ng d\u1ecbch chi\u1ebft ti\u1ec3u c\u1ea7u v\u00e0 ph\u1ee9c h\u1ee3p \u00e1nh s\u00e1ng \u0111\u01a1n s\u1eafc. Qu\u00e1 tr\u00ecnh n\u00e0y c\u00f3 t\u00e1c d\u1ee5ng \u0111\u00e1nh th\u1ee9c\/ ho\u1ea1t h\u00f3a c\u00e1c t\u1ebf b\u00e0o g\u1ed1c (ASCs) \u0111ang \u1edf d\u1ea1ng ch\u01b0a ho\u1ea1t \u0111\u1ed9ng. C\u00e1c t\u1ebf b\u00e0o ho\u1ea1t h\u00f3a sau \u0111\u00f3 \u0111\u01b0\u1ee3c ti\u00eam v\u00e0o v\u00f9ng c\u01a1 tim b\u1ec7nh theo protocol \u0111\u1eb7c bi\u1ec7t (\u0111\u01b0\u1ee3c tr\u00ecnh b\u00e0y chi ti\u1ebft \u1edf ph\u1ea7n quy tr\u00ecnh chi ti\u1ebft). To\u00e0n b\u1ed9 quy tr\u00ecnh ph\u00e2n l\u1eadp, k\u00edch ho\u1ea1t t\u1ebf b\u00e0o k\u00e9o d\u00e0i trong kho\u1ea3ng 4h \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n trong ph\u00f2ng ph\u1eabu thu\u1eadt ho\u1eb7c m\u1ed9t ph\u00f2ng kh\u00e1c \u0111\u1ee7 ti\u00eau chu\u1ea9n v\u1ec1 v\u00f4 tr\u00f9ng.<\/p>\n<h2><\/h2>\n<h2><span style=\"text-decoration: underline;\">8.\u00a0\u00a0\u00a0\u00a0\u00a0 T\u1ebf b\u00e0o g\u1ed1c tr\u01b0\u1edfng th\u00e0nh t\u1eeb m\u00f4 m\u1ee1 l\u00e0 g\u00ec?<\/span><\/h2>\n<p>ASCs, n\u00f3i m\u1ed9t c\u00e1ch kh\u00e1c l\u00e0 c\u00e1c t\u1ebf b\u00e0o g\u1ed1c \u0111a n\u0103ng \u0111\u1eb7c hi\u1ec7u c\u1ee7a m\u1ed9t m\u00f4 c\u1ee5 th\u1ec3 n\u00e0o \u0111\u00f3 \u0111\u01b0\u1ee3c cho th\u1ea5y l\u00e0 d\u01b0\u1edbi c\u00e1c \u0111i\u1ec1u ki\u1ec7n c\u1ee5 th\u1ec3 th\u00edch h\u1ee3p c\u00f3 kh\u1ea3 n\u0103ng bi\u1ec7t h\u00f3a th\u00e0nh nhi\u1ec1u lo\u1ea1i t\u1ebf b\u00e0o kh\u00e1c nhau, bao g\u1ed3m c\u1ea3 c\u00e1c t\u1ebf b\u00e0o t\u1eeb c\u00e1c ngu\u1ed3n l\u00e1 ph\u00f4i kh\u00e1c. Hi\u1ec7n t\u01b0\u1ee3ng n\u00e0y \u0111\u01b0\u1ee3c cho l\u00e0 c\u00f3 li\u00ean quan t\u1edbi t\u00ednh bi\u1ec7t h\u00f3a ch\u00e9o (transdifferentiation) v\u00e0 t\u1ea1o h\u00ecnh c\u1ee7a t\u1ebf b\u00e0o g\u1ed1c. C\u00e1c \u0111i\u1ec1u ki\u1ec7n c\u1ee5 th\u1ec3 th\u00edch h\u1ee3p cho qu\u00e1 tr\u00ecnh bi\u1ec7t h\u00f3a ch\u00e9o l\u00e0 do s\u1ef1 t\u00e1c \u0111\u1ed9ng c\u1ee7a m\u00f4i tr\u01b0\u1eddng nu\u00f4i c\u1ea5y trong \u1edf \u0111i\u1ec1u ki\u1ec7n th\u00ed nghi\u1ec7m ho\u1eb7c do qu\u00e1 tr\u00ecnh c\u1ea5y gh\u00e9p c\u00e1c t\u1ebf b\u00e0o g\u1ed1c v\u00e0o m\u1ed9t c\u01a1 quan, m\u1ed9t d\u1ea1ng m\u00f4 c\u01a1 th\u1ec3 kh\u00e1c v\u1edbi n\u01a1i ch\u00fang \u0111\u01b0\u1ee3c ph\u00e2n l\u1eadp. Tuy nhi\u00ean, c\u01a1 ch\u1ebf ch\u00ednh x\u00e1c gi\u1ea3i th\u00edch cho s\u1ef1 bi\u1ec7t h\u00f3a n\u00e0y v\u1eabn \u0111ang c\u00f2n l\u00e0 v\u1ea5n \u0111\u1ec1 tranh c\u00e3i.<\/p>\n<p>C\u00e1c ASCs c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb m\u00f4 m\u1ee1 c\u1ee7a ng\u01b0\u1eddi \u0111\u01b0\u1ee3c thu nh\u1eadn th\u00f4ng qua vi\u1ec7c h\u00fat m\u1ee1. Nh\u1eefng t\u1ebf b\u00e0o g\u1ed1c n\u00e0y c\u00f3 c\u00e1c \u0111\u1eb7c \u0111i\u1ec3m t\u01b0\u01a1ng \u0111\u1ed3ng v\u1edbi c\u00e1c t\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 \u0111\u01b0\u1ee3c ph\u00e2n l\u1eadp t\u1eeb t\u1ee7y x\u01b0\u01a1ng \u0111\u00e3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong c\u00e1c li\u1ec7u ph\u00e1p c\u1ea5y gh\u00e9p t\u1ebf b\u00e0o g\u1ed1c t\u1ef1 th\u00e2n t\u1eeb h\u01a1n hai th\u1eadp k\u1ec9 tr\u01b0\u1edbc. S\u1ef1 t\u01b0\u01a1ng \u0111\u1ed3ng r\u00f5 r\u1ec7t gi\u1eefa hai lo\u1ea1i ASCs th\u1ec3 hi\u1ec7n \u1edf c\u1ea3 m\u1eb7t h\u00ecnh th\u00e1i, s\u1ef1 ph\u00e1t tri\u1ec3n v\u00e0 c\u00e1c t\u00ednh ch\u1ea5t b\u1ec1 m\u1eb7t c\u1ee7a t\u1ebf b\u00e0o gi\u1eefa c\u00e1c t\u1ebf b\u00e0o g\u1ed1c c\u00f3 ngu\u1ed3n g\u1ed1c m\u00f4 m\u1ee1 v\u00e0 c\u00e1c t\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb t\u1ee7y x\u01b0\u01a1ng. Ngo\u00e0i ra, c\u00e1ch th\u1ee9c ph\u00e1t tri\u1ec3n c\u1ee7a ch\u00fang trong m\u00f4i tr\u01b0\u1eddng in vitro v\u00e0 in vivo c\u0169ng c\u00f3 s\u1ef1 t\u01b0\u01a1ng \u0111\u1ed3ng. Do \u0111\u00f3, ng\u01b0\u1eddi ta cho r\u1eb1ng th\u1ef1c t\u1ebf c\u00e1c t\u1ebf b\u00e0o g\u1ed1c m\u00f4 m\u1ee1 l\u00e0 t\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 t\u1ed3n t\u1ea1i trong m\u00f4 m\u1ee1. Tuy nhi\u00ean, v\u1ec1 m\u1eb7t l\u00e2m s\u00e0ng, c\u00e1c t\u1ebf b\u00e0o g\u1ed1c m\u00f4 m\u1ee1 c\u00f3 m\u1ed9t s\u1ed1 l\u1ee3i th\u1ebf nh\u01b0 \u0111\u00e3 \u0111\u1ec1 c\u1eadp, \u0111\u00f3 l\u00e0 s\u1ed1 l\u01b0\u1ee3ng l\u1edbn, th\u1ee7 thu\u1eadt thu nh\u1eadn d\u1ec5 d\u00e0ng, \u00edt g\u00e2y \u0111au \u0111\u1edbn h\u01a1n so v\u1edbi t\u1ee7y x\u01b0\u01a1ng. \u0110i\u1ec1u n\u00e0y, v\u1ec1 m\u1eb7t l\u00fd thuy\u1ebft c\u00f3 ngh\u0129a l\u00e0 vi\u1ec7c c\u1ea5y gh\u00e9p c\u00e1c t\u1ebf b\u00e0o g\u1ed1c m\u00f4 m\u1ee1 s\u1ebd kh\u00f4ng ch\u1ec9 ho\u1ea1t \u0111\u1ed9ng v\u00e0 thu \u0111\u01b0\u1ee3c c\u00e1c th\u00e0nh c\u00f4ng \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh nh\u01b0 t\u1ebf b\u00e0o g\u1ed1c t\u1ee7y x\u01b0\u01a1ng m\u00e0 c\u00f2n c\u00f3 l\u1ee3i \u00edch trong vi\u1ec7c gi\u1ea3m c\u00e1c m\u1ed1i nguy c\u01a1 cho b\u1ec7nh nh\u00e2n.<\/p>\n<p>V\u1ec1 m\u1eb7t l\u00ed thuy\u1ebft, ASCs c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb m\u00f4 m\u1ee1, l\u00e0 m\u1ed9t c\u00f4ng c\u1ee5 tr\u1ecb li\u1ec7u c\u00f3 \u01b0u th\u1ebf, l\u00ed do \u0111\u1ea7u ti\u00ean c\u1ee7a vi\u1ec7c n\u00e0y l\u00e0 <strong>s\u1ed1 l\u01b0\u1ee3ng r\u1ea5t l\u1edbn<\/strong> c\u00e1c ASCs c\u00f3 th\u1ec3 thu \u0111\u01b0\u1ee3c t\u1eeb m\u00f4 m\u1ee1, th\u1ee9 hai l\u00e0 do n\u00f3 lo\u1ea1i b\u1ecf \u0111\u01b0\u1ee3c y\u00eau c\u1ea7u nu\u00f4i gia t\u0103ng s\u1ed1 l\u01b0\u1ee3ng \u0111\u1ec3 \u0111\u00e1p \u1ee9ng li\u1ec1u \u0111i\u1ec1u tr\u1ecb, th\u1ee9 ba l\u00e0 k\u0129 thu\u1eadt thu nh\u1eadn d\u1ec5 d\u00e0ng \u00edt g\u00e2y \u0111au \u0111\u1edbn, gi\u1ea3m thi\u1ec3u nguy c\u01a1 cho b\u1ec7nh nh\u00e2n v\u00e0 th\u1ee9 t\u01b0 l\u00e0 h\u1ed7n h\u1ee3p c\u1ee7a c\u00e1c th\u00e0nh ph\u1ea7n thu \u0111\u01b0\u1ee3c t\u1eeb qu\u00e1 tr\u00ecnh h\u00fat m\u1ee1. Ch\u00fang t\u00f4i xin gi\u1ea3i th\u00edch c\u1ee5 th\u1ec3 h\u01a1n v\u1ec1 qu\u00e1 tr\u00ecnh h\u00fat m\u1ee1 n\u00e0y.<\/p>\n<p>Ngo\u1ea1i tr\u1eeb c\u00e1c t\u1ebf b\u00e0o m\u1ee1, trong m\u00f4 m\u1ee1 c\u00f2n ch\u1ee9a r\u1ea5t nhi\u1ec1u lo\u1ea1i t\u1ebf b\u00e0o kh\u00e1c nhau bao g\u1ed3m c\u00e1c ti\u1ec1n t\u1ebf b\u00e0o m\u1ee1, t\u1ebf b\u00e0o n\u1ed9i m\u00f4, c\u00e1c t\u1ebf b\u00e0o c\u01a1 tr\u01a1n, t\u1ebf b\u00e0o ngo\u1ea1i m\u1ea1ch, nguy\u00ean b\u00e0o s\u1ee3i v\u00e0 ASCs. Th\u1ee7 thu\u1eadt h\u00fat m\u1ee1, do t\u00ednh ch\u1ea5t c\u1ee7a ph\u01b0\u01a1ng ph\u00e1p n\u00e0y n\u00ean ch\u00fang c\u00f3 th\u1ec3 thu nh\u1eadn c\u1ea3 c\u00e1c d\u1ea1ng t\u1ebf b\u00e0o c\u00f3 trong m\u00e1u nh\u01b0 c\u00e1c t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch (t\u1ebf b\u00e0o Lympho B v\u00e0 T, c\u00e1c t\u1ebf b\u00e0o Natural Killer, \u0111\u1ea1i th\u1ef1c b\u00e0o, c\u00e1c b\u1ea1ch c\u1ea7u \u0111\u01a1n nh\u00e2n), c\u00e1c t\u1ebf b\u00e0o g\u1ed1c t\u1ea1o m\u00e1u, ho\u1eb7c c\u00e1c ti\u1ec1n t\u1ebf b\u00e0o n\u1ed9i m\u00f4.<\/p>\n<p>Qu\u00e1 tr\u00ecnh h\u00fat m\u1ee1, th\u00eam v\u00e0o \u0111\u00f3 c\u00f2n gi\u00fap thu nh\u1eadn th\u00eam c\u00e1c y\u1ebfu t\u0103ng tr\u01b0\u1edfng TGF \u2013 \u03b2, c\u00e1c y\u1ebfu t\u1ed1 t\u0103ng tr\u01b0\u1edfng c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb ti\u1ec3u c\u1ea7u, c\u00e1c y\u1ebfu t\u1ed1 t\u0103ng tr\u01b0\u1edfng nguy\u00ean b\u00e0o s\u1ee3i (FGF), trong s\u1ed1 c\u00e1c ch\u1ea5t li\u1ec7u kh\u00e1c nhau th\u00ec c\u00e1c y\u1ebfu t\u1ed1 n\u00e0y h\u1ed7 tr\u1ee3 ch\u1eb7t ch\u1ebd s\u1ef1 t\u1ed3n t\u1ea1i c\u1ee7a c\u00e1c t\u1ebf b\u00e0o m\u1ee1 trong m\u1ed9t c\u1ea5u tr\u00fac ngo\u1ea1i b\u00e0o xung quanh n\u00f3, v\u00ed d\u1ee5 nh\u01b0 trong m\u00f4 m\u1ee1. C\u1ea5u tr\u00fac ngo\u1ea1i b\u00e0o n\u00e0y c\u0169ng ch\u1ee9a c\u00e1c protein laminnin.<\/p>\n<p>ASCs c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb m\u00f4 m\u1ee1 trong c\u00e1c \u0111i\u1ec1u ki\u1ec7n th\u00edch h\u1ee3p \u1edf m\u00f4i tr\u01b0\u1eddng in vitro \u0111\u01b0\u1ee3c cho th\u1ea5y l\u00e0 c\u00f3 kh\u1ea3 n\u0103ng bi\u1ec7t h\u00f3a th\u00e0nh x\u01b0\u01a1ng, s\u1ee5n, m\u1ee1, c\u01a1, t\u1ebf b\u00e0o th\u1ea7n kinh, m\u1ea1ch m\u00e1u<sup>.<\/sup> Khi ph\u00e2n l\u1eadp c\u00e1c t\u1ebf b\u00e0o mang marker CD45<sup>&#8211;<\/sup>, CD34<sup>+<\/sup>, CD105<sup>+<\/sup> th\u00e0nh 2 qu\u1ea7n th\u1ec3 CD31<sup>+<\/sup> v\u00e0 CD31<sup>&#8211;<\/sup>, ng\u01b0\u1eddi ta th\u1ea5y r\u1eb1ng c\u00e1c t\u1ebf b\u00e0o n\u1ed9i m\u00f4 kh\u00f4ng c\u00f3 marker CD31, t\u1ee9c l\u00e0 CD31<sup>&#8211;<\/sup> c\u00f3 kh\u1ea3 n\u0103ng bi\u1ec7t h\u00f3a th\u00e0nh m\u1ee1, x\u01b0\u01a1ng, s\u1ee5n v\u00e0 c\u00e1c t\u1ebf b\u00e0o th\u1ea7n kinh. Trong khi \u0111\u00f3, qu\u1ea7n th\u1ec3 c\u00f3 CD31<sup>+<\/sup> gi\u00fap t\u00e2n t\u1ea1o m\u1ea1ch m\u00e1u ho\u1eb7c c\u00f3 t\u00e1c d\u1ee5ng th\u00fac \u0111\u1ea9y v\u00e0 h\u1ed7 tr\u1ee3 s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a c\u00e1c m\u1ea1ch m\u00e1u hi\u1ec7n c\u00f3. T\u1ef7 l\u1ec7 cao (29.2%) c\u00e1c t\u1ebf b\u00e0o mang CD90<sup>\u00a0 <\/sup>mang l\u1ea1i kh\u1ea3 n\u0103ng cao bi\u1ec7t h\u00f3a th\u00e0nh t\u1ebf b\u00e0o c\u01a1. T\u01b0\u01a1ng t\u1ef1 nh\u01b0 v\u1eady, c\u00e1c t\u1ebf b\u00e0o ti\u1ec1n t\u1ea1o m\u00e1u trong qu\u1ea7n th\u1ec3 m\u1ee1 ch\u1ecdc h\u00fat c\u00f2n gi\u00fap t\u0103ng c\u01b0\u1eddng h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch. C\u00e1c nghi\u00ean c\u1ee9u c\u0169ng ch\u1ec9 ra r\u1eb1ng s\u1ef1 hi\u1ec7n di\u1ec7n c\u1ee7a c\u00e1c marker b\u1ec1 m\u1eb7t t\u1ebf b\u00e0o CD11b v\u00e0 CD11c c\u1ee7a c\u00e1c \u0111\u1ea1i th\u1ef1c b\u00e0o v\u00e0 c\u00e1c t\u1ebf b\u00e0o t\u1ee7y x\u01b0\u01a1ng trong qu\u1ea7n th\u1ec3 m\u1ee1 ch\u1ecdc h\u00fat\u00a0 trong khi protein laminin \u0111\u01b0\u1ee3c cho l\u00e0 c\u00f3 t\u00e1c \u0111\u1ed9ng \u0111\u00e1ng k\u1ec3 l\u00ean s\u1ef1 t\u00e1i t\u1ea1o c\u00e1c t\u1ebf b\u00e0o th\u1ea7n kinh.<\/p>\n<p>Do \u0111\u00f3, m\u1eb7c d\u00f9 c\u00e1c nghi\u00ean c\u1ee9u \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng c\u00e1c ASCs t\u1eeb m\u00f4 m\u1ee1 d\u01b0\u1edbi c\u00e1c \u0111i\u1ec1u ki\u1ec7n ph\u00f9 h\u1ee3p c\u00f3 kh\u1ea3 n\u0103ng bi\u1ec7t h\u00f3a th\u00e0nh nhi\u1ec1u lo\u1ea1i t\u1ebf b\u00e0o kh\u00e1c nhau, ch\u00fang t\u00f4i tin r\u1eb1ng c\u00e1c th\u00e0nh ph\u1ea7n kh\u00e1c trong qu\u1ea7n th\u1ec3 t\u1ebf b\u00e0o ch\u1ecdc h\u00fat thu \u0111\u01b0\u1ee3c ho\u1ea1t \u0111\u1ed9ng nh\u01b0 m\u1ed9t nh\u00e2n t\u1ed1 h\u1ed7 tr\u1ee3 cho vi\u1ec7c t\u0103ng c\u01b0\u1eddng hi\u1ec7u qu\u1ea3 c\u1ee7a ASCs t\u1eeb m\u00f4 m\u1ee1.<\/p>\n<p>Ng\u01b0\u1eddi ta c\u0169ng nh\u1eadn th\u1ea5y r\u1eb1ng kh\u1ed1i t\u1ebf b\u00e0o g\u1ed1c ASCs t\u01b0\u01a1i, \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng ngay, kh\u00f4ng th\u00f4ng qua m\u1ed9t ph\u01b0\u01a1ng th\u1ee9c k\u00edch ho\u1ea1t n\u00e0o, k\u00e9m hi\u1ec7u qu\u1ea3 h\u01a1n kh\u1ed1i t\u1ebf b\u00e0o \u0111\u00e3 \u0111\u01b0\u1ee3c k\u00edch ho\u1ea1t, v\u00ed d\u1ee5 nh\u01b0 b\u1eb1ng \u1ee7 \u1ea5m trong 1 gi\u1edd, k\u00edch ho\u1ea1t b\u1eb1ng PRP&#8230; ASCs m\u00f4 m\u1ee1 thu \u0111\u01b0\u1ee3c t\u1eeb qu\u1ea7n th\u1ec3 m\u1ee1 ch\u1ecdc h\u00fat \u0111\u1ec1u \u1edf tr\u1ea1ng th\u00e1i ng\u1ee7 do \u0111\u00f3 ch\u00fang c\u1ea7n \u0111\u01b0\u1ee3c k\u00edch ho\u1ea1t \u0111\u1ea7y \u0111\u1ee7 v\u1ec1 m\u1eb7t ch\u1ee9c n\u0103ng \u0111\u1ec3 b\u1eaft \u0111\u1ea7u qu\u00e1 tr\u00ecnh t\u1ef1 l\u00e0m m\u1edbi th\u00f4ng qua qu\u00e1 tr\u00ecnh ph\u00e2n chia t\u1ebf b\u00e0o v\u00e0 h\u00ecnh th\u00e0nh c\u00e1c d\u1ea1ng t\u1ebf b\u00e0o kh\u00e1c nh\u1edd kh\u1ea3 n\u0103ng bi\u1ec7t h\u00f3a.<\/p>\n\n\t\t<\/div> \n\t<\/div> \n\t\t<\/div> \n\t<\/div> \n\n\t<div class=\"vc_col-sm-4 wpb_column vc_column_container \">\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<!-- vc_grid start -->\n<div class=\"vc_grid-container wpb_content_element vc_basic_grid\" data-vc-grid-settings=\"{&quot;page_id&quot;:7660,&quot;style&quot;:&quot;all&quot;,&quot;action&quot;:&quot;vc_get_vc_grid_data&quot;,&quot;animation_in&quot;:&quot;zoomIn&quot;,&quot;shortcode_id&quot;:&quot;{failed_to_get_id:\\&quot;vc_gid:1443242713385-7797dbee-b52a-6\\&quot;}&quot;,&quot;tag&quot;:&quot;vc_basic_grid&quot;}\" data-vc-request=\"\/wp-admin\/admin-ajax.php\" data-vc-post-id=\"7660\">\n<\/div><!-- vc_grid end -->\n\n\t\t<\/div> \n\t<\/div> \n<\/div><div class=\"opn-row-pre-element\" data-opn_enable_overlay=\"\" data-id=\"\" data-gutter=\"\"><\/div>\n","protected":false},"excerpt":{"rendered":"C\u00f4ng ngh\u1ec7 t\u1ebf b\u00e0o g\u1ed1c Ch\u1ed1ng l\u00e3o h\u00f3a v\u00e0 c\u1ea3i thi\u1ec7n m\u1ed9t nh\u00f3m c\u00e1c b\u1ec7nh tho\u00e1i h\u00f3a. C\u00e1c v\u1eadn \u0111\u1ed9ng vi\u00ean s\u1eed d\u1ee5ng c\u00f4ng ngh\u1ec7 PRP ADISTEM .tp-caption.medium_text,.medium_text{position:absolute;color:#fff;text-shadow:0px 2px 5px rgba(0,0,0,0.5);font-weight:700;font-size:20px;line-height:20px;font-family:Arial;margin:0px;border-width:0px;border-style:none;white-space:nowrap}.tp-caption.largepinkbg,.largepinkbg{font-size:23px;line-height:31px;font-weight:300;font-family:\"Open Sans\";color:rgb(255,255,255);text-decoration:none;padding:0px 20px;text-shadow:none;background-color:rgb(219,67,96);border-width:0px;border-color:rgb(255,255,255);border-style:none}.tp-caption.medium_bg_red,.medium_bg_red{font-size:20px;line-height:20px;font-weight:800;font-family:\"Open Sans\";color:rgb(255,255,255);text-decoration:none;background-color:rgb(227,58,12);padding:10px;border-width:0px;border-color:rgb(255,214,88);border-style:none} \/****************************************** - PREPARE PLACEHOLDER FOR SLIDER - ******************************************\/ var setREVStartSize = function() { var tpopt = new Object(); tpopt.startwidth = 960; [...]","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-7660","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"http:\/\/www.ggb.vn\/index.php?rest_route=\/wp\/v2\/pages\/7660","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.ggb.vn\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/www.ggb.vn\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/www.ggb.vn\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"http:\/\/www.ggb.vn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=7660"}],"version-history":[{"count":5,"href":"http:\/\/www.ggb.vn\/index.php?rest_route=\/wp\/v2\/pages\/7660\/revisions"}],"predecessor-version":[{"id":8351,"href":"http:\/\/www.ggb.vn\/index.php?rest_route=\/wp\/v2\/pages\/7660\/revisions\/8351"}],"wp:attachment":[{"href":"http:\/\/www.ggb.vn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=7660"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}